Enhancing Surgical Performance...
... Optimising Ocular Protection
VISIOL® - a unique viscoelastic for cataract surgery
VISIOL® contains 2% sodium hyaluronate and mannitol.
COHESIVE & DISPERSIVE
VISIOL® displays both cohesive and dispersive behaviours. An optimal viscosity of 60,000 mPas at zero shear rate has been reached with the right balance between sodium hyaluronate (SH) molecular weight (1.8 million Da) and concentration (2%).
VISIOL® is adapted to all the different stages of the cataract surgery procedure:
- Space creation
- Lens implantation
COHESIVE & DISPERSIVE
VISIOL® efficiently covers the anterior chamber tissues as well as instruments and IOL due to its low angle of contact.1
LOW POST-OPERATIVE IOP
Intraocular pressure (IOP) increase is considered a major post-operative consequence in cataract surgery despite viscoelastic removal. A clinical trial has shown that VISIOL® did not cause clinically significant elevation of IOP1 (see the figure below).
PROTECTIVE ROLE OF MANNITOL: FREE RADICAL SCAVENGING
VISIOL® is a unique viscoelastic that contains the special combination of sodium hyaluronate and mannitol, a linear sugar-alcohol. Mannitol demonstrated the ability to prevent rapid breakdown of sodium hyaluronate chains by scavenging reactive oxygen species (ROS) (fig.1).
Fig. 1: Mannitol reacts with ROS slowing down the degradation of the SH chains.
The phacoemulsification step can generate ROS3. Thanks to the mannitol contained in VISIOL®, the SH chains are protected against rapid depolymerisation. As a result, the product viscosity is maintained sufficiently high during the complete cataract surgery procedure until its removal (fig. 2).
Fig. 2: Inhibitory effect of 30 mM of mannitol on SH degradation
VISIOL® IS DESIGNED FOR THE HAND OF THE SURGEON ...
SURVEY PERFORMED ON 10 SURGEONS, DATA ON FILE.
... AND FOR THE EYE OF THE PATIENT
1 TRB Chemedica, data on file.
Overall, VISIOL® offers the optimum characteristics thoughout cataract surgery ...
... while providing good protection to the patient
Sodium hyaluronate 2%
Molecular weight: 1.8 million Da
Produced by bacterial fermentation
Cohesive & dispersive behaviours
Protective role of mannitol against rapid depolymerisation
Zero shear rate viscosity: 60,000 mPas
Volume of product: 1.0 ml
One glass syringe with Luer-Lok
Terminally steam sterilised
Storage conditions: 2-25º C
3-year shelf life
TRB CHEMEDICA AG
85540 Haar/München, Germany
TRB CHEMEDICA (UK) Ltd
Lymedale Business Park