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Once the synovial fluid is flushed out of the joint, the balance of the articular environment is lost. Replacement of the synovial fluid with hyaluronan may promote restoration of homeostasis inside the joint.
Studies have shown that exogenous hyaluronan:
Saline irrigation significantly inhibits cartilage metabolism, as shown by reduced 35S-sulphate incorporation into proteoglycans. It is restored to normal by the addition of hyaluronan16
Following partial meniscectomy, hyaluronan promotes meniscal regeneration compared with saline29
Exogenous hyaluronan stimulates healing of damage to the anterior cruciate ligament (ACL)33